Stenotrophomonas maltophilia complex: insights into evolutionary relationships, global distribution and pathogenicity.

ABSTRACT:

Introduction

Stenotrophomonas maltophilia complex (Smc) comprises opportunistic Gram-negative bacilli responsible for various nosocomial infections. Limited data exists concerning its evolutionary lineage, global prevalence and pathogenicity.

Methods

We conducted an extensive genomic analysis on 734 Smc genomes, of which 90 were newly sequenced and isolated from different patients. The species composition and evolutionary relationships of Smc were examined using core protein sequence analysis. Pathogenicity evaluation was used by assays for swimming motility, biofilm formation and identification of virulence factors. The broth microdilution method was used to evaluate the drug resistance spectrum of clinical isolates.

Results

Phylogenetic analyses delineated 24

SUBMITTER: Li K 

PROVIDER: S-EPMC10806987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature