Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis.

ABSTRACT:

Background

Observational studies have explored the association of psychiatric disorders and the risk of brain cancers. However, the causal effect of specific mental illness on glioma remains elusive due to the lack of solid evidence.

Methods

We performed a two-sample bidirectional Mendelian randomization (MR) analysis to explore the causal relationships between 5 common psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorder, and panic disorder) and glioma. Summary statistics for psychiatric disorders and glioma were extracted from Psychiatric Genomics Consortium (PGC) and 8 genome-wide association study (GWAS) datasets respectively. We calculated the MR estimates for odds ratio of glioma associated with each psychiatric di

SUBMITTER: Yang W 

PROVIDER: S-EPMC10807081 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature