Relationship between autism and brain cortex surface area: genetic correlation and a two-sample Mendelian randomization study.

ABSTRACT:

Background

Alterations in surface area (SA) in specific regions of the cortex have been reported in many individuals with autism spectrum disorder (ASD), however, the genetic background between ASD and SA is still unclear. This study estimated the genetic correlation and causal effect of ASD and cortical SA.

Methods

Summarized data of genome-wide association studies (GWAS) were separately downloaded from the Psychiatric Genomics Consortium (18,381 cases of ASD, and 27,969 controls) and the Enhancing Neuroimaging Genetics through Meta-Analysis Consortium (33,992 participants of Europeans). We used Linkage disequilibrium score regression (LDSC) and Heritability Estimation from Summary Statistics (HESS) to calculate the heritability of each trait. As for the genetic correlation

SUBMITTER: Li X 

PROVIDER: S-EPMC10807092 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature