Fibronectin mediates activin A-promoted human trophoblast migration and acquisition of endothelial-like phenotype.

ABSTRACT:

Background

During human early placentation, a proportion of extravillous trophoblasts (EVTs) migrate to the maternal decidua, differentiating into endovascular EVTs to remodel spiral arteries and ensure the establishment of blood circulation at the maternal-fetal interface. Inadequate EVT migration and endovascular differentiation are closely associated with adverse pregnancy outcomes such as miscarriage. Activin A and fibronectin are both secretory molecules abundantly expressed at the maternal-fetal interface. Activin A has been reported to regulate EVT biological functions. However, whether fibronectin mediates activin A-promoted EVT migration and acquisition of endothelial-like phenotype as well as the underlying molecular mechanisms remain unknown. Additionally, the role of fi

SUBMITTER: Lan X 

PROVIDER: S-EPMC10807102 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature