Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases.

ABSTRACT: Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and symptoms that are linked to specific cell populations in the brain. Notably, the immune system has been implicated in both diseases, with a particular focus on the dysfunction of microglia, the brain's resident immune cells, contributing to neuronal loss and exacerbating symptoms. Researchers use models of the neuroimmune system to gain a deeper understanding of the physiological and biological aspects of these neurodegenerative diseases and how they progress. Several in vitro and in vivo models, including 2D cultures and animal models, have been utilized. Recently, advancements have bee

SUBMITTER: Balestri W 

PROVIDER: S-EPMC10807115 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature