Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial.

ABSTRACT:

Background

Current hypertension guidelines recommend combination of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker with a calcium-channel blocker or thiazide diuretic as initial antihypertensive therapy in patients with monotherapy uncontrolled hypertension. However, to what extent these two different combinations are comparable in blood pressure (BP)-lowering efficacy and safety remains under investigation, especially in the Chinese population. We investigated the BP-lowering efficacy and safety of the amlodipine/benazepril and benazepril/hydrochlorothiazide dual therapies in Chinese patients.

Methods

In a multi-center, randomized, actively controlled, parallel-group trial, we enrolled patients with stage 1 or 2 hypertension from July 2018 to Jun

SUBMITTER: Huang QF 

PROVIDER: S-EPMC10807184 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature