Platelet Transfusion and Death or Neurodevelopmental Impairment in Children Born Extremely Preterm.

ABSTRACT:

Importance

Infants born extremely preterm receive transfusions at higher platelet count thresholds than older children and adults due to concerns for intracranial hemorrhage. A recent randomized trial comparing 2 platelet transfusion thresholds showed the higher threshold was associated with increased risk of long-term adverse neurodevelopmental outcomes.

Objective

To evaluate the association of platelet transfusion exposure with death and severe neurodevelopmental impairment (NDI) at 2 years' corrected age in a cohort of infants born extremely preterm.

Design, setting, and participants

An observational cohort study and secondary analysis of the Preterm Erythropoietin Neuroprotection Trial, a randomized, placebo-controlled clinical trial of erythropoietin neuroprotect

SUBMITTER: Davenport PE 

PROVIDER: S-EPMC10807258 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature