Effect of High BMI on Human Bone Marrow-Derived Mesenchymal Stromal Cells.

ABSTRACT: Bone marrow-derived mesenchymal stromal cells (BMSCs) are attractive candidates in tissue engineering and regenerative medicine. Growing evidence has suggested that a high body mass index (BMI) can affect the properties of BMSCs, resulting in a reduced quality of the cells. However, the results are not consistent. Therefore, this study aimed to investigate the influences of high BMI on human BMSCs (hBMSCs). To avoid gender bias, BMSCs from females and males were studied independently. Finally, hBMSCs from 89 females and 152 males were separately divided into the normal BMI group (18.5 kg/m² ≤ BMI < 25 kg/m²) and the high BMI group (BMI > 25 kg/m²). The cells were analyzed for the colony-forming potential; proliferation capacity; in vitro adipogenic,

SUBMITTER: Zong Q 

PROVIDER: S-EPMC10807335 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature