Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.

ABSTRACT: The Ets domain transcription factors direct diverse biological processes throughout all metazoans and are implicated in development as well as in tumor initiation, progression and metastasis. The Drosophila Ets transcription factor Pointed (Pnt) is the downstream effector of the Epidermal growth factor receptor (Egfr) pathway and is required for cell cycle progression, specification, and differentiation of most cell types in the larval eye disc. Despite its critical role in development, very few targets of Pnt have been reported previously. Here, we employed an integrated approach by combining genome-wide single cell and bulk data to identify putative cell type-specific Pnt targets. First, we used chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) to determine the gen

SUBMITTER: Bollepogu Raja KK 

PROVIDER: S-EPMC10807358 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature