Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials.

ABSTRACT:

Background

The impact of fibroblasts on the immune system provides insight into the function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes interact with immunocytes by secreting growth factors, cytokines, and chemokines, leading to wound healing, fibrosis, and escape of cancer immune surveillance. However, the specific mechanisms involved in the fibroblast-immunocyte interaction network have not yet been fully elucidated.

Main body and conclusion

Therefore, we systematically reviewed the molecular mechanisms of fibroblast-immunocyte interactions in fibrosis, from the history of cellular evolution and cell subtype divisions to the regulatory networks between fibroblasts and immunocytes. We also discuss how these communications function in d

SUBMITTER: Di X 

PROVIDER: S-EPMC10807359 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature