Cone-Driven, Geniculocortical Responses in Canine Models of Outer Retinal Disease.

ABSTRACT:

Purpose

Canine models of inherited retinal degeneration are used for proof of concept of emerging gene and cell-based therapies that aim to produce functional restoration of cone-mediated vision. We examined functional magnetic resonance imaging (MRI) measures of the postretinal response to cone-directed stimulation in wild-type (WT) dogs, and in three different retinal disease models.

Methods

Temporal spectral modulation of a uniform field of light around a photopic background was used to target the canine L/M (hereafter "L") and S cones and rods. Stimuli were designed to separately target the postreceptoral luminance (L+S) and chrominance (L-S) pathways, the rods, and all photoreceptors jointly (light flux). These stimuli were presented to WT, and mutant PDE6B-RCD1, RPGR-X

SUBMITTER: Taskin HO 

PROVIDER: S-EPMC10807495 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature