Hemolysis in reverse grouping: Evaluation and implication of high titer isoagglutinin of two blood donors.

ABSTRACT: Hemolysis is a positive agglutination reaction and is primarily associated with high anti-A or anti-B antibody titers. This high titer may result in no agglutination due to the "prozone" phenomenon. Platelet concentrate of high titer has an adverse effect on the recipient of the non-identical ABO blood group. Similarly, the blood products with higher titers of isoagglutinin have recently increased the incidence of intravenous immunoglobulins-related hemolysis. In this Asian subcontinent, the impact of O blood donors with high antibody titers or ABO incompatible platelets is hardly addressed. Blood was collected from two healthy donors and subjected to blood grouping as done routinely. Hemolysis was observed in the reverse grouping with the "B-"cell. Blood grouping was repeated with the con

SUBMITTER: Routray SS 

PROVIDER: S-EPMC10807518 | biostudies-literature | 2023 Jul-Dec

REPOSITORIES: biostudies-literature