Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American men.

ABSTRACT:

Background

Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined the relationships of gentrification with prostate cancer and serum proteome-defined inflammation and immune function in a diverse cohort.

Methods

The case-control study included 769 cases [405 African American (AA), 364 European American (EA) men] and 1023 controls (479 AA and 544 EA), with 219 all-cause and 59 prostate cancer-specific deaths among cases. Geocodes were linked to a neighborhood gentrification index (NGI) derived from US Census data. Cox and logistic regression, and MANOVA, were used to determine associations between NGI, as

SUBMITTER: Pichardo CM 

PROVIDER: S-EPMC10807554 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature