Brain white matter microstructural changes in chemotherapy-treated older long-term breast cancer survivors.

ABSTRACT:

Purpose

To assess white matter microstructural changes in older long-term breast cancer survivors 5-15 years post-chemotherapy treatment.

Methods

Breast cancer survivors aged 65 years or older who underwent chemotherapy (C+) and who did not undergo chemotherapy (C-) and age- and sex-matched healthy controls (HC) were enrolled at time point 1 (TP1) and followed for 2 years for time point 2 (TP2). All participants underwent brain MRI with diffusion tensor images and neuropsychological (NP) testing with the NIH Toolbox Cognition Battery. Tract-based spatial statistics (TBSS) analysis was performed on the diffusion tensor images to assess white matter microstructural changes with the fractional anisotropy (FA) parameter.

Results

There were significant longitudinal alterat

SUBMITTER: Daniel E 

PROVIDER: S-EPMC10807556 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature