Blood regulator of G protein signalling 1 as a potential prognostic biomarker in surgical nonsmall cell lung cancer patients: Correlation with clinical features and survival.

ABSTRACT:

Introduction

Regulator of G protein signalling 1 (RGS1) closely regulates malignant phenotypes and tumour immunity in several cancers, while its clinical value in nonsmall cell lung cancer (NSCLC) is by far rarely reported. Consequently, this study aimed to explore the linkage of blood RGS1 with clinical features and prognosis in surgical NSCLC patients.

Methods

Two-hundred and ten surgical NSCLC patients were consecutively enrolled in this study, whose RGS1 in peripheral blood mononuclear cells was determined before treatment via reverse transcriptional-quantitative polymerase chain reaction. Additionally, the blood RGS1 was also collected from 30 healthy controls (HCs).

Results

Blood RGS1 was increased in NSCLC patients compared with HCs (P < 0.001). Elevated blood

SUBMITTER: Wang L 

PROVIDER: S-EPMC10807578 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature