The causal relationship between osteoarthritis and bladder cancer: A Mendelian randomization study.

ABSTRACT:

Objective

The causal association between osteoarthritis (OA) and bladder cancer remains unclear. This Mendelian randomization (MR) study was carried out to assess the potential causal effects of any OA, knee OA and hip OA, and bladder cancer.

Method

Genome-wide association study (GWAS) summary data for OA and bladder cancer were obtained in GWAS CATALOG, UK Biobank, and FinnGen Consortium. Inverse-variance weighted (IVW) approach was primarily conducted to evaluate the causal relationships between OA and bladder cancer, and MR-Egger intercept and Cochran's Q test were mainly used to estimate heterogeneity and pleiotropy. MR-PRESSO was used to test the presence of horizontal outliers. Leave-one-out analysis was utilized to ensure the reliability of the results.

Results

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10807596 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature