Construction of immune score and its prognostic value in invasive lobular carcinoma of the breast using computational pathology analysis.

ABSTRACT:

Background

Previous studies have shown that high level of TILs in invasive lobular carcinoma (ILC) is associated with poor prognosis, contrary to that in TNBC and HER2-positive breast cancer.

Methods

The densities of six immune cell markers and three immune checkpoints in the ILC microenvironment were detected by computational pathology analysis. Then, the LASSO cox regression model was used to construct an immune score (IS) and further evaluate its prognostic value.

Results

In our ILC cohort, the low density of CD4, CD8, CD20, CD56, CD68, FOXP3, PD-1, and PD-L1 had significantly longer disease-free survival (DFS) and overall survival (OS); however, the low density of CTLA-4 was associated with shorter DFS and OS. Based on this, an IS was constructed, and patients wit

SUBMITTER: Wang L 

PROVIDER: S-EPMC10807639 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature