Exploration of treatment-free remission in CML, based on molecular monitoring.

ABSTRACT:

Background

Typical chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm caused by t(9; 22)(q34; q11) translocation. This chromosomal translocation forms the BCR::ABL1 fusion gene. The tyrosine kinase encoded by the BCR::ABL1 is considered to be the main pathogenic diver. BCR::ABL1 is not only a therapeutic target, but also a monitoring target. Monitoring of BCR::ABL1 reveals the progression of the disease and guides the next treatment. Now for CML, the target of treatment has been focused on treatment-free remission (TFR).

Methods

We conducted a literature review of current developments of treatment-free remission and molecular monitoring methods.

Results

More effective and sensitive CML monitoring methods such as digital droplet PCR (ddPCR) and next ge

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10807643 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature