Role of cAMP in Cardiomyocyte Viability: Beneficial or Detrimental?

ABSTRACT:

Background

3', 5'-cyclic AMP (cAMP) regulates numerous cardiac functions. Various hormones and neurotransmitters elevate intracellular cAMP (i[cAMP]) in cardiomyocytes through activating GsPCRs (stimulatory-G-protein-coupled-receptors) and membrane-bound ACs (adenylyl cyclases). Increasing evidence has indicated that stimulating different GsPCRs and ACs exhibits distinct, even opposite effects, on cardiomyocyte viability. However, the underlying mechanisms are not fully understood.

Methods

We used molecular and pharmacological approaches to investigate how different GsPCR/cAMP signaling differentially regulate cardiomyocyte viability with in vitro, ex vivo, and in vivo models.

Results

For prodeath GsPCRs, we explored β1AR (beta1-adrenergic receptor) and H2R (histamine

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10807647 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature