Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties.

ABSTRACT:

Introduction

There are many intra-articular hyaluronic acid (IA-HA) products on the market that have known intrinsic differences in molecular size, source, and structure. The current review summarizes existing evidence describing and assessing these differences, while also identifying whether these differences have an impact on clinical outcomes.

Methods

This systematic review summarized all literature that specifically addresses IA-HA product differences. Included studies summarized basic science and mechanism of action comparisons of IA-HA product differences, or systematic reviews that assess differences in clinical outcomes between IA-HA product differences.

Results

A total of 20 investigations assessed basic science differences between IA-HA products, while 20 in

SUBMITTER: Ferkel E 

PROVIDER: S-EPMC10807741 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature