Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection.

ABSTRACT: Toxoplasma gondii is an obligate intracellular parasite that infects one-third of the world's human population and establishes infection in the brain. Cerebral immune cell infiltration is critical for controlling the parasite, but little is known about the molecular cues guiding immune cells to the brain during infection. Activated astrocytes produce CCL2, a chemokine that mediates inflammatory monocyte recruitment to tissues by binding to the CCR2 receptor. We detected elevated CCL2 production in the brains of C57BL/6J mice by 15 days after T. gondii infection. Utilizing confocal microscopy and intracellular flow cytometry, we identified microglia and brain-infiltrating myeloid cells as the main producers of CCL2 during acute infection, and CCL2 was specifically produced in regions of par

SUBMITTER: Orchanian SB 

PROVIDER: S-EPMC10807779 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature