Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry.

ABSTRACT:

Background

Depression and anxiety are the most common mental health problems in young people. Currently, clinicians are advised to wait before initiating treatment for young people with these disorders as many spontaneously remit. However, others develop recurrent disorder but this subgroup cannot be identified at the outset. We examined whether psychiatric polygenic scores (PGS) could help inform stratification efforts to predict those at higher risk of recurrence.

Methods

Probable emotional disorder was examined in two UK population cohorts using the emotional symptoms subscale of the Strengths and Difficulties Questionnaire (SDQ). Those with emotional disorder at two or more time points between ages 5 and 25 years were classed as 'recurrent emotional disorder' (n = 1,643)

SUBMITTER: Dennison CA 

PROVIDER: S-EPMC10807819 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature