Cellular development and evolution of the mammalian cerebellum.

ABSTRACT: The expansion of the neocortex, a hallmark of mammalian evolution^1,2, was accompanied by an increase in cerebellar neuron numbers³. However, little is known about the evolution of the cellular programmes underlying the development of the cerebellum in mammals. In this study we generated single-nucleus RNA-sequencing data for around 400,000 cells to trace the development of the cerebellum from early neurogenesis to adulthood in human, mouse and the marsupial opossum. We established a consensus classification of the cellular diversity in the developing mammalian cerebellum and validated it by spatial mapping in the fetal human cerebellum. Our cross-species analyses revealed largely conserved developmental dynamics of cell-type generation, except for Purkinje cells, for

SUBMITTER: Sepp M 

PROVIDER: S-EPMC10808058 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature