Host genetic regulation of human gut microbial structural variation.

ABSTRACT: Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established^1-6, little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a meta-analysis of associations between human genetic variation and gut microbial structural variation in 9,015 individuals from four Dutch cohorts. Strikingly, the presence rate of a structural variation segment in Faecalibacterium prausnitzii that harbours an N-acetylgalactosamine (GalNAc) utilization gene cluster is higher in individuals who secrete the type A oligosaccharide antigen terminating in GalNAc, a feature that is jointly determined by human ABO and FUT2 genotypes, and we could replicate this association in a Tanzanian cohort. In vitr

SUBMITTER: Zhernakova DV 

PROVIDER: S-EPMC10808065 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature