The Effect of Inhaled Corticosteroids on Pneumonia Risk in Patients With COPD-Bronchiectasis Overlap: A UK Population-Based Case-Control Study.

ABSTRACT:

Background

Inhaled corticosteroids (ICS) increase the risk of pneumonia in COPD and commonly are used in patients with COPD-bronchiectasis overlap.

Research question

Is the risk of pneumonia associated with ICS further heightened in COPD-bronchiectasis?

Study design and methods

Electronic health care records (from 2004-2019) were used to obtain a cohort of patients with COPD and a nested case-control group (age and sex matched 1:4). Analyses were conducted to determine the risk of hospitalization for pneumonia in COPD associated with ICS use in those with bronchiectasis. Findings were confirmed by several sensitivity analyses. Additionally, a smaller nested case-control group containing only patients with COPD-bronchiectasis overlap and those with recent blood eosinop

SUBMITTER: Ritchie AI 

PROVIDER: S-EPMC10808068 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature