Severe Pulmonary Hypertension in COPD: Impact on Survival and Diagnostic Approach.

ABSTRACT:

Background

Severe pulmonary hypertension (PH) is prognostically highly relevant in patients with COPD. The criteria for severe PH have been defined based on hemodynamic thresholds in right heart catheterization.

Research question

Can noninvasive clinical tools predict severe PH in patients with COPD? How does the mortality risk change with increasing severity of airflow limitation and pulmonary vascular disease?

Study design and methods

We retrospectively analyzed all consecutive patients with COPD with suspected PH undergoing in-depth clinical evaluation, including right heart catheterization, in our PH clinic between 2005 and 2018. Clinical variables potentially indicative of severe PH or death were analyzed using univariate and stepwise multivariate logistic regres

SUBMITTER: Kovacs G 

PROVIDER: S-EPMC10808070 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature