Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.

ABSTRACT:

Background

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. Corticosteroids may be a beneficial adjunct in the treatment of bacterial pneumonia.

Research question

Is there any benefit of corticosteroid therapy in the management of bacterial CAP among patients requiring hospitalization?

Study design and methods

PubMed, Cochrane Library, and Embase were searched to identify randomized controlled trials assessing the use of systemic corticosteroids compared with standard care in the management of CAP. A systematic review, meta-analysis, and Trial Sequential Analysis (TSA) were performed. The primary outcome was all-cause mortality. Secondary outcomes included ICU admission, mechanical ventilation, treatment failure, readmission, and adver

SUBMITTER: Saleem N 

PROVIDER: S-EPMC10808071 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature