Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.

ABSTRACT:

Introduction

Platelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone. Furthermore, platelets trigger acute inflammation and cardiac remodeling leading to alterations in scar formation and cardiac function as observed in thrombocytopenic mice. GPVI is the major collagen receptor in platelets and important for platelet activation and thrombus formation and stability. Antibody induced deletion of GPVI at the platelet surface or treatment of mice with recombinant GPVI-Fc results in reduced inflammation and decreased infarct size in a mouse model of AMI. However, the role of GPVI has not been fully clarified to date.

Methods/results

In this study, we found that GPVI is

SUBMITTER: Reusswig F 

PROVIDER: S-EPMC10808189 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature