Role of metabolomic profile as a potential marker to discriminate membranous nephropathy from IgA nephropathy.

ABSTRACT:

Background

Membranous nephropathy (MN) and IgA nephropathy (IgAN) are the most common primary glomerulopathies worldwide. The systemic metabolic changes in the progression of MN and IgAN are not fully understood.

Methods

A total of 87 and 70 patients with MN and IgAN, respectively, and 30 healthy controls were enrolled in this study. Untargeted metabolomics was performed to explore the differential metabolites and metabolic pathways in the early stage of MN and IgAN. To judge the diagnostic ability of biomarkers, receiver operating characteristic curve analysis (ROC) were performed.

Results

Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) suggested that patients with MN and IgAN showed an obvious separation trend

SUBMITTER: Qu Y 

PROVIDER: S-EPMC10808257 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature