Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry.

ABSTRACT:

Purpose

According to recent reports, cannabigerol (CBG) concentration level in blood and body fluids may have forensic utility as a highly specific albeit insensitive biomarker of recent cannabis smoking. While the analytical sensitivity of cannabidiol (CBD), Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabichromene (CBC) or cannabinol (CBN) estimation by gas chromatography-mass spectrometry (GC-MS) is similar and sufficiently high, it is exceptionally low in the case of CBG (ca. 25 times lower than for the other mentioned cannabinoids). The purpose of this study is to explain the reasons for the extremely low analytical sensitivity of GC-MS in estimating CBG and to present possible ways of its improvement.

Methods

Nuclear magnetic resonance (NMR) data and GC-M

SUBMITTER: Dawidowicz AL 

PROVIDER: S-EPMC10808273 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature