M⁶A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation.

ABSTRACT: 3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure to PAHs has been thought of as an important factor in urothelial tumorigenesis. N⁶-methyladenosine (m⁶A) exists widely in eukaryotic organisms and regulates the expression level of specific genes by regulating mRNA stability, translation efficiency, and nuclear export efficiency. Currently, the potential molecular mechanisms that regulate m⁶A modification for 3-MC carcinogenesis remain unclear. Here, we profiled mRNA, m⁶A, translation and protein level using "-omics" methodologies, including transcriptomes, m⁶A profile, translatomes, and proteomics in 3-MC-transformed urothelial cells and control cells. The key mole

SUBMITTER: Liu B 

PROVIDER: S-EPMC10808315 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature