Randomized trial to assess the potential role of ascorbic acid and statin for post-contrast acute kidney injury prevention.

ABSTRACT:

Purpose

To evaluate the effect of using statins and ascorbic acid for the prevention of post-contrast acute kidney injury (PC-AKI) in patients undergoing urologic diagnostic elective contrast-enhanced computed tomography (CECT).

Methods

This registered trial (NCT03391830) was for statin naïve patients underwent elective CECT. Patients were randomized allocated to two groups: the first group received atorvastatin 80-mg the day before the study and atorvastatin 40-mg two hours before the CECT and for continue on atorvastatin 40-mg two days after CECT; plus ascorbic acid 500 mg with atorvastatin. The other group received two tablets of placebo once/daily before the procedure and for another 3 days. The primary outcome was to assess the incidence PC-AKI.

Results

The basel

SUBMITTER: Hashem A 

PROVIDER: S-EPMC10808395 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature