Clinical importance in Alzheimer's disease: effects of anchor agreement and disease severity.

ABSTRACT:

Objectives

Methods of evaluating clinically meaningful decline are critical in research on Alzheimer's disease. A common method of quantifying clinically meaningful change is to calculate an anchor-based minimal clinically important difference (MCID) score. In this approach, individuals who report a meaningful change serve as the "anchors", and the mean level of change for this group serves as the MCID. In research on Alzheimer's disease, there are several possible anchors, including patients, knowledgeable observers (e.g., a family member), and clinicians. The goal of this study was to examine the extent to which agreement among anchors impacts MCID estimation and whether this relationship is moderated by cognitive severity status.

Methods

Analyses were completed on a longi

SUBMITTER: Stojanovic M 

PROVIDER: S-EPMC10808396 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature