Identification and validation of a prognostic risk-scoring model for AML based on m⁷G-associated gene clustering.

ABSTRACT:

Background

Acute myeloid leukemia (AML) patients still suffer from poor 5-year survival and relapse after remission. A better prognostic assessment tool is urgently needed. New evidence demonstrates that 7-methylguanosine (m7G) methylation modifications play an important role in AML, however, the exact role of m7G-related genes in the prognosis of AML remains unclear.

Methods

The study obtained AML expression profiles and clinical information from TCGA, GEO, and TARGET databases. Using the patient data from the TCGA cohort as the training set. Consensus clustering was performed based on 29 m7G-related genes. Survival analysis was performed by KM curves. The subgroup characteristic gene sets were screened using WGCNA. And tumor immune infiltration correlation analysis was per

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10808397 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature