Myeloid cell MHC I expression drives CD8⁺ T cell activation in nonalcoholic steatohepatitis.

ABSTRACT:

Background & aims

Activated CD8⁺ T cells are elevated in Nonalcoholic steatohepatitis (NASH) and are important for driving fibrosis and inflammation. Despite this, mechanisms of CD8⁺ T cell activation in NASH are largely limited. Specific CD8⁺ T cell subsets may become activated through metabolic signals or cytokines. However, studies in NASH have not evaluated the impact of antigen presentation or the involvement of specific antigens. Therefore, we determined if activated CD8⁺ T cells are dependent on MHC class I expression in NASH to regulate fibrosis and inflammation.

Methods

We used H2Kb and H2Db deficient (MHC I KO), Kb transgenic mice, and myeloid cell Kb deficient mice (LysM Kb KO) to investigate how MHC class I impac

SUBMITTER: Adams VR 

PROVIDER: S-EPMC10808415 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature