Unravelling the mechanisms of underweight in Parkinson's disease by investigating into the role of gut microbiome.

ABSTRACT: Approximately half of patients with Parkinson's disease (PD) suffer from unintentional weight loss and are underweight, complicating the clinical course of PD patients. Gut microbiota alteration has been proven to be associated with PD, and recent studies have shown that gut microbiota could lead to muscle wasting, implying a possible role of gut microbiota in underweight PD. In this study, we aimed to (1) investigate the mechanism underlying underweight in PD patients with respect to gut microbiota and (2) estimate the extent to which gut microbiota may mediate PD-related underweight through mediation analysis. The data were adapted from Hill-Burns et al., in which 330 participants (199 PD, 131 controls) were enrolled in the study. Fecal samples were collected from participants for microb

SUBMITTER: Shih LC 

PROVIDER: S-EPMC10808448 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature