Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.

ABSTRACT: The function of neuronal networks is determined not only by synaptic connectivity but also by neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular constraints that organize neuromodulatory signaling in the telencephalon of adult zebrafish, we used transcriptomics and additional approaches to delineate cell types, to determine their phylogenetic conservation, and to map the expression of marker genes at high granularity. The combinatorial expression of GPCRs and cell-type markers indicates that all neuronal cell types are subject to modulation by multiple monoaminergic systems and distinct combinations of neuropeptides. Individual cell types were associated with multiple (typically >30) neuromodulatory signaling

SUBMITTER: Anneser L 

PROVIDER: S-EPMC10808507 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature