Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium.

ABSTRACT: What regulates organ size and shape remains one fundamental mystery of modern biology. Research in this area has primarily focused on deciphering the regulation in time and space of growth and cell division, while the contribution of cell death has been overall neglected. This includes studies of the Drosophila wing, one of the best-characterized systems for the study of growth and patterning, undergoing massive growth during larval stage and important morphogenetic remodeling during pupal stage. So far, it has been assumed that cell death was relatively neglectable in this tissue both during larval stage and pupal stage, and as a result, the pattern of growth was usually attributed to the distribution of cell division. Here, using systematic mapping and registration combined with quantita

SUBMITTER: Matamoro-Vidal A 

PROVIDER: S-EPMC10808510 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature