Rational use of eculizumab in secondary atypical hemolytic uremic syndrome.

ABSTRACT:

Background

Secondary atypical hemolytic uremic syndrome (secondary aHUS) is a heterogeneous group of thrombotic microangiopathies (TMA) associated with various underlying conditions. Unlike primary aHUS, there is still no hard evidence on the efficacy of complement blockade in secondary aHUS, since the two main series that investigated this subject showed discrepant results. Our work aims to reassess the efficacy of eculizumab in treating secondary aHUS.

Methods

Observational, retrospective, single-center study, in which we analyzed the hematological and renal evolution of 23 patients diagnosed with secondary aHUS who received treatment with eculizumab and compared them with a control cohort of 14 patients. Complete renal response was defined as the recovery of renal functio

SUBMITTER: Cordero L 

PROVIDER: S-EPMC10808527 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature