Germinal centers are permissive to subdominant antibody responses.

ABSTRACT:

Introduction

A protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the antibody response. Antigens can display various levels of immunogenicity, and a hierarchy of immunodominance arises when the GC response to an antigen dampens the response to other antigens. Immunodominance is a challenge for the development of vaccines to mutating viruses, and for the development of broadly neutralizing antibodies. The extent by which antigens with different levels of immunogenicity compete for the induction of high affinity antibodies and therefore contribute to immunodominance is not known.

Methods

Here, we perf

SUBMITTER: Robert PA 

PROVIDER: S-EPMC10808553 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature