GiRAff: an automated atlas segmentation tool adapted to single histological slices.

ABSTRACT: Conventional histology of the brain remains the gold standard in the analysis of animal models. In most biological studies, standard protocols usually involve producing a limited number of histological slices to be analyzed. These slices are often selected into a specific anatomical region of interest or around a specific pathological lesion. Due to the lack of automated solutions to analyze such single slices, neurobiologists perform the segmentation of anatomical regions manually most of the time. Because the task is long, tedious, and operator-dependent, we propose an automated atlas segmentation method called giRAff, which combines rigid and affine registrations and is suitable for conventional histological protocols involving any number of single slices from a given mouse brain. In pa

SUBMITTER: Piluso S 

PROVIDER: S-EPMC10808556 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature