Tick innate immune responses to hematophagy and <i>Ehrlichia</i> infection at single-cell resolution.

ABSTRACT:

Introduction

Ticks rely on robust cellular and humoral responses to control microbial infection. However, several aspects of the tick's innate immune system remain uncharacterized, most notably that of the immune cells (called hemocytes), which are known to play a significant role in cellular and humoral responses. Despite the importance of hemocytes in regulating microbial infection, our understanding of their basic biology and molecular mechanisms remains limited. Therefore, we believe that a more detailed understanding of the role of hemocytes in the interactions between ticks and tick-borne microbes is crucial to illuminating their function in vector competence and to help identify novel targets for developing new strategies to block tick-borne pathogen transmission.

Methods

SUBMITTER: Adegoke A 

PROVIDER: S-EPMC10808623 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature