Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.

ABSTRACT: Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases. These proteins are actively pursued as promising drug targets, benefitting greatly from advances in structural and mechanistic studies of TRP channels. At the same time, the complex, polymodal activation and regulation of TRP channels have presented formidable challenges. In this short review, we summarize recent progresses toward understanding the structural basis of TRP channel function, as well as potential ligand binding sites that could be targeted for therapeutics. A particular focus is on the current understanding of the molecular mechanisms of TRP channel activation and re

SUBMITTER: Huang J 

PROVIDER: S-EPMC10808746 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature