Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study.

ABSTRACT:

Background

Many previous studies have revealed a close relationship between lipoprotein metabolism and sepsis, but their causal relationship has, until now, remained unclear. Therefore, we performed a two-sample Mendelian randomization analysis to estimate the causal relationship of lipoprotein-associated phospholipids with the risk of sepsis.

Materials and methods

A two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship between lipoprotein-associated phospholipids and sepsis based on large-scale genome-wide association study (GWAS) summary statistics. MR analysis was performed using a variety of methods, including inverse variance weighted as the primary method, MR Egger, weighted median, simple mode, and weighted mode as compl

SUBMITTER: Zeng L 

PROVIDER: S-EPMC10808779 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature