The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Poor glycemic control with elevated levels of hemoglobin A1c (HbA1c) is associated with increased risk of cognitive impairment, with potentially varying effects between sexes. However, the causal impact of poor glycemic control on white matter brain aging in men and women is uncertain.

Methods

We used two nonoverlapping data sets from UK Biobank cohort: gene-outcome group (with neuroimaging data, (N = 15,193; males/females: 7,101/8,092)) and gene-exposure group (without neuroimaging data, (N = 279,011; males/females: 122,638/156,373)). HbA1c was considered the exposure and adjusted "brain age gap" (BAG) was calculated on fractional anisotropy (FA) obtained from brain imaging as the outcome, thereby representing the difference between predicted and ch

SUBMITTER: Tian C 

PROVIDER: S-EPMC10808780 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature