Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families.

ABSTRACT: Introduction: Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health problem worldwide. T1DM is a result of a combination of genetics, epigenetics, and environmental factors. Several genes have been associated with T1DM, including HLA, INS, CTLA4, and PTPN22. However, none of these findings have been based on linkage analysis because it is rare to find families with several diabetic individuals. Two Palestinian families with several afflicted members with variations in the mode of inheritance were identified and selected for this study. This study aimed to identify the putative causative gene(s) responsible for T1DM development in these families to i

SUBMITTER: Bawatneh A 

PROVIDER: S-EPMC10808782 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature