Genetically predicted chronic rhinosinusitis and the risk of stroke: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

The causal association between chronic rhinosinusitis (CRS) and stroke remains uncertain due to the susceptibility of observational studies to confounding and the possibility of reverse causality. This study aims to examine the potential causal relationship between CRS and the risk of stroke, encompassing various subtypes.

Methods

In this research, we utilized genome-wide association study (GWAS) data for CRS from FinnGen. We identified significant single-nucleotide polymorphisms (SNPs) associated with CRS and used them as instrumental variables (IVs). GWAS data for any ischemic stroke (AIS), ischemic stroke (IS), large-artery atherosclerotic stroke (LAS), small-vessel strokes (SVS), cardioembolic strokes (CES), intracerebral hemorrhage (ICH), lobar ICH, and non-lo

SUBMITTER: Hu J 

PROVIDER: S-EPMC10808795 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature