Association between human blood metabolome and the risk of delirium: a Mendelian Randomization study.

ABSTRACT:

Background

Delirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which are acknowledged detrimental outcomes. Nonetheless, the current strategies for predicting and managing delirium remain constrained. Our aim was to employ Mendelian randomization (MR) to investigate the potential causal relationship between metabolites and delirium, as well as to identify potential therapeutic targets.

Methods

We identified 129 distinct blood metabolites from three genome-wide association studies (GWASs) conducted on the metabolome, involving a total of 147,827 participants of European descent. Genetic informat

SUBMITTER: Long C 

PROVIDER: S-EPMC10808797 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature