Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.

ABSTRACT:

Background

Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).

Objectives

This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.

Methods

Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta

SUBMITTER: Monangi NK 

PROVIDER: S-EPMC10808817 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature