Association of perioperative plasma concentration of neurofilament light with delirium after cardiac surgery: a nested observational study.

ABSTRACT:

Background

Neurofilament light is a blood-based biomarker of neuroaxonal injury that can provide insight into perioperative brain vulnerability and injury. Prior studies have suggested that increased baseline and postoperative concentrations of neurofilament light are associated with delirium after noncardiac surgery, but results are inconsistent. Results have not been reported in cardiac surgery patients, who are among those at highest risk for delirium. We hypothesised that perioperative blood concentrations of neurofilament light (both baseline and change from baseline to postoperative day 1) are associated with delirium after cardiac surgery.

Methods

This study was nested in a trial of arterial blood pressure targeting during cardiopulmonary bypass using cerebral autoreg

SUBMITTER: Brown CH 

PROVIDER: S-EPMC10808824 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature